The mouse is (in, on, under, in front of, next to, behind, between…) the box.
In front of: The position directly ahead of someone or something; the most forward position or place.The leading part or surface of anything.
Behind: Behind is the contrary of In front of. It means at the back (part) of something.
On: On refers to something that is in a position that is physically touching, covering or attached to something under it.
In: Not out; within; inside.
Next to: beside
Under/Below: Under and below have a similar meaning. They refer to something at a lower level. (Something is above it).
Between: Between generally means that something is in the middle of two objects or people (or places).
Over/Above: Above and Over have a similar meaning. They both refer to a “X object” that is “at a higher position than Y” but above normally refers to being directly (vertically) above you.